Fresh analysis suggests that people who come off blockbuster weight-loss injections like Mounjaro or Wegovy may regain lost weight at a significantly accelerated pace than those who end conventional diet and exercise programs.
Findings released in a prominent health publication shows that while obese people often shed a large proportion of their body weight while undergoing treatment, the weight is regained at an average rate of 0.8 kg per month after stopping.
"Individuals purchasing these treatments must be cognizant of the risk of rapid weight regain when the medication concludes," cautioned lead investigator Dr. Susan Jebb.
Such speed of regain suggests a return to starting weight in about 18 months.
Comparing Approaches
The analysis, which reviewed dozens of studies involving thousands of participants, contrasted the effects of these new drugs with other pills.
The team emphasize that people who lose weight through dieting typically experience a slower creep back—approximately 100 grams monthly—once they finish.
Understanding the Rapid Rebound
Experts suggest the way of the drugs accounts for the heightened regain.
GLP-1 drugs copy a natural hormone called GLP-1, which controls feelings of fullness.
"Long-term administration of GLP-1 levels several times higher than normal could lead to the system to generate a reduced amount of its own natural hormone, and may also reduce responsiveness to its actions," noted Dr. Adam Collins, a nutrition specialist.
"Discontinuation of this medication results in appetite is no longer kept in check, making excessive eating far more likely."
An Ongoing Condition?
The NHS recommend the jabs for individuals with weight-linked medical conditions, accompanied by recommended lifestyle changes.
Many experts contend that, considering the likelihood of weight regain, the therapy is often life-long.
This perspective is reinforced by drug manufacturers, who say that the findings "emphasize the chronic character of excess weight," similar to managing diseases like diabetes.
Patient Testimonies
Individuals who have stopped the jabs explain a sudden return of cravings.
"It was like something activating and you're instantly starving," said one woman.
This challenge is exacerbated if individuals have not established lasting lifestyle or habit modifications during therapy.
Significant Adoption
Figures suggest that millions of adults in the UK have used these injections in the past year, with interest remaining high.
- Use is higher among women than males.
- The middle-aged age group shows the highest usage rates.
- A large proportion obtain the medications through private healthcare rather than public health services.
Finally, experts caution that while these medications are potent tools for shedding pounds, they are not a standalone fix and maintained weight loss hinges on ongoing behavioural changes.
